Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase–1
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چکیده
منابع مشابه
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.
Effective therapies for the treatment of obesity, a key element of metabolic syndrome, are urgently needed but currently lacking. Stearoyl-CoA desaturase-1 (SCD1) is the rate-limiting enzyme catalyzing the conversion of saturated long-chain fatty acids into monounsaturated fatty acids, which are major components of triglycerides. In the current study, we tested the efficacy of pharmacological i...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2005
ISSN: 0021-9738
DOI: 10.1172/jci200523962